Contraindications

Contraindications to Metvix® Use5

  • Metvix® is not recommended during pregnancy.
  • Thick (hyperkeratotic) actinic keratoses should not be treated with Metvix®. There is no experience of treating lesions which are pigmented, highly infiltrating or are located on the genitalia.
  • There is no experience of treating BD lesions larger than 40 mm. As with cryotherapy and 5-FU therapy of BD response rates of large lesions (>20 mm in diameter) are lower than those of small lesions.
  • There is no experience of treating BD in transplant patients on immunosuppressive therapy or in patients with a history of arsenic exposure.
  • Methyl aminolevulinate may cause sensitisation by skin contact. The excipient cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis), methyl- and propylparahydroxybenzoate (E218, E216) may cause allergic reactions (possibly delayed).
  • Any UV-therapy should be discontinued before treatment. As a general precaution, sun exposure on the treated lesion sites and surrounding skin has to be avoided for a couple of days following treatment.
  • Direct eye contact with Metvix® cream should be avoided.

References